Indianapolis Colts vs. San Francisco 49ers, at San Francisco

Kickoff: Sunday, September 22nd, at 4:25PM Eastern

Line: San Francisco -10 Total: 46.5

Will the Indianapolis Colts find a way to rebound, while they are on the road, against a real contender, the San Francisco 49ers? What kind of role will new player Trent Richardson play in this contest? As online sportsbook bettors ask themselves these questions, the Colts are 10 point underdogs at YouWager.

Indianapolis is coming from their loss to the Miami Dolphins, and two of their top starters on the offense will be out for the 2013 NFL football wagering season with injuries. With Trent Richardson added to the team, Indianapolis now has three of the top picks from the 2012 NFL Draft that included their young quarterback, Andrew Luck. Aside from the usual stats, there will be some interesting personal factors at play on Sunday. At some point in this matchup, Indianapolis cornerback Vontae Davis may be covering his own brother, San Francisco tight end Vernon Davis. Internet football bettors can also expect to hear sportscasters make much of the fact that San Francisco’s head coach, Jim Harbaugh, was Andrew Luck’s coach in college. Indianapolis lost that game to Miami by only 4 points, as Luck struggled against the Dolphins’ defense. In that game, Indianapolis gave up 319 passing yards. The Colts’ defense will have to make serious adjustments if they hope to make the kind of impact on San Francisco’s quarterback, Colin Kaepernick that the Seattle Seahawks did.

The 49ers also have a loss to forget about. Last weekend, San Francisco did not look their best when the Seattle Seahawks demolished them in a 29-3 blowout. Clearly, the 49ers will have to move past that embarrassing defeat if they are going to advance to the playoffs. Both of these teams will trying to bounce back from losing games, but the 49ers still get the leading edge for their home advantage at YouWager. The Indianapolis Colts will be crossing two time zones to play the 49ers at home. San Francisco is 16-6-1 against the spread in their last 23 games at home.

Surprisingly, Indianapolis has a great winning record all-time against San Francisco, 24-18. Since the Colts moved to Indianapolis, these two teams have only squared off 7 times, and San Francisco has won 4 of those matchups. The last time these two clubs faced each other, in 2009, Indianapolis won 18-14. At YouWager, the 49ers are posted as a 10 point favorite. The Total is 46.5. Game time on Sunday is 4:25PM Eastern.


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